can you have paracetamol after alcohol

The acidosis was present before the onset of clinical hepatic failure and was associated with hyperlactataemia up to 202 mmol l 1 in two patients. Acute alcohol intake may diminish an individuals ability to metabolise large doses of paracetamol the plasma half-life of which can be prolonged.

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. Paracetamol concentrations in blood should be measured more than 4 hours after an overdose in order to be able to assess the risk of developing liver damage via the paracetamol overdose nomogram. Administration of oral methionine or intravenous N-acetyl cysteine NAC which may have a beneficial effect up to at least 48 hours after the overdose. Chronic alcohol intake can increase the hepatotoxicity of paracetamol overdose and may have contributed to the acute pancreatitis reported in one patient who had taken an overdose of paracetamol. Three patients who presented 48 h after paracetamol ingestion had severe metabolic acidosis pH 714727 accompanied by hypotension peripheral vasoconstriction and dehydration.